Lamellipodium in 3D
The term “lamellipodia” was coined first by Abercrombie and co-workers to describe the thin sheet-like extensions at the front of migrating cells, to distinguish these from “filopodia”, the finger-like projections commonly seen together with lamellipodia at the cell periphery.
The three dimensional organization of lamellipodia has been resolved by electron tomography.
The Arp2/3 complex fits in the electron density of actin branch junctions in lamellipodia.
The first steps in lamellipodia formation can be studied by monitoring the repair of cytoplasm after wounding.